Category Archives: Clinical Reference

Syncope

In 2017, the American College of Cardiology (ACC) / American Heart Association (AHA) Task Force on Clinical Practice Guidelines and the Heart Rhythm Society released their practice guideline on the evaluation and management of patient with syncope (pdf). It is a massive document. Of the 278 pages, the references, appendix, and data supplement combined take up 210 pages. The Admin EM

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Pulmonary Embolism Algorithm

The American College of Emergency Physicians recently revised its clinical policy on the evaluation of adults presenting to the emergency department with suspected acute venous thromboembolic disease. It was published in the May issue of Annals of Emergency Medicine and is available to read here. The revision answers 5 key questions regarding the evaluation and treatment of patients with thromboembolic

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Assessing Clinical Evidence

There are always numerous opinions regarding the relevance and quality of clinical studies. As we seek to determine the validity of conclusions given by authors, it is important to develop a consistent approach to the evaluation of the evidence. Here is one such method: 1) What is the question being asked? This is important to understand before proceeding further because

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Tranexamic Acid (TXA)

Tranexamic acid is a synthetic form of lysine, an amino acid. It is classified as an “anti-fibrinolytic” which means it is a  pro-coagulant. It binds to receptors on plasmin preventing it from breaking down fibrin clots. Tranexamic acid was originally discovered in 1962 and is currently on the World Health Organization’s list of Essential Medicines.  The drug has been studied

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