TypeNameOnsetPeakDurationComments
Ultra Short Acting (Rapid)Aspart (Fiasp)2.5 min1 hr3-4 hrsMay be taken up to 20 min after meal start. Do not mix in syringe with other types of insulin.
Aspart (Novolog)<15 min1-3 hr3-5 hrsDo not mix in syringe with other types of insulin.
Glulisine (Apidra)
<30 min0.5-1.5 hrs3-5 hrsDo not mix in syringe with other types of insulin.
Inhaled Insulin (Afrezza)<15min0.5 hr3 hrs
Lispro (Admelog, Humalog)15 min05.1.5 hrs3-5 hrsDo not mix in syringe with other types of insulin.
Short ActingRegular (Humilin-R, Novolin-R) 100 and 500 u/ml30 min2-4 hrs6-12 hrs (6-24 hrs for 500 u/ml)Usually taken about 30 minutes before a meal. 500 u/ml may not be mixed in syringe with other types.
Combination Intermediate / Ultra ShortAspart Protamine/ Aspart (Novolog mix)
<15 min1-4 hrs12-24 hrsDo not mix in syringe with other types of insulin.
Lispro Protamine/ Lispro (Humalog mix)
<30 min1-4 hrs6-12 hrsDo not mix in syringe with other types of insulin.
Combination Intermediate / Short ActingNPH/ Regular (Humulin mix, Novolin mix)
30 min2-12 hrs18-24 hrsDo not mix in syringe with other types of insulin.
Intermediate ActingNPH (Humulin N, Novolin N)
1-2 hrs4-12 hrs14-24 hrsCan be mixed w/ rapid or short-acting insulin in syringe
Long ActingDegludec (Tresiba)
1 hrN/A42 hrsDo not mix in syringe with other types of insulin.
Detemir (Levemir)1 hrN/A12-24 hrsDo not mix in syringe with other types of insulin.
Glargine (Lantus 100 u/ml, Tujeo 300u/ml)6 hrsN/A24-36 hrsDo not mix in syringe with other types of insulin.
References:
  1. Epocrates Online “Insulin Comparison” Link
  2. American Diabetes Association. Insulin Basics. April 7, 2014. American Diabetes Association. Available at Link.
  3. Medscape “Insulin Types” Link
  4. Mayo Clinic Online “Insulin: Compare common options for insulin therapy” Link

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